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Section of Neurology, Department of Medicine, University of Perugia, Perugia, ItalyInstitute of Neuroscience and Physiology Department of Psychiatry and Neurochemistry, The Sahlgrenska AcademyUniversity of Gothenburg, Mlndal, SwedenLaboratory of Neurophysiology, IRCCS Fondazione Santa Lucia, Rome, ItalyDepartment of Molecular Neuroscience, UCL Institute of Neurology Queen Square, London, UKUK Dementia Research Institute at UCL, London, United KingdomAbstractIn the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases.
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